Showtime's Californication will end after its upcoming seventh season, the network has announced.
The show's final run, consisting of 12 episodes, will begin in April 2014.
Showtime has announced that the remainder of the comedy will wrap up the storylines of its characters, including Hank Moody played by David Duchovny.
Showtime's president of entertainment David Nevins said:
"With its unique blend of lyricism and excess, Californication has been one of our groundbreaking signature series.
"We will always be indebted to Tom Kapinos for leading the creative charge on this memorable comedy, and to David Duchovny for making us root for an unapologetic hedonist like Hank Moody.
"Tom has carefully planned the final chapter of Hank's journey and has brought it to a beautiful and satisfying conclusion for new and longtime fans alike."
Rob Lowe is confirmed to be reprising his role as eccentric actor Eddie Nero in at least one episode of the show's seventh run.
Roger Howarth, Heather Graham and Mary Lynn Rajskub will also guest star in the final season.